A group of Yale scientists is one bit nearer to utilizing the ribosome — the cell’s protein-production manufacturing plant — to make architect polymers, including more grounded and increasingly adaptable materials and life-sparing medications.
The ribosome has an astounding ability to embed the novel structure blocks of polymers toward the start of a protein sequence, the scientists report in journal ACS Central Science.
“This paper reports that the ribosome can start protein amalgamation with molecules like those found in Kevlar or the precursors to significant antibiotics,” said Alanna Schepartz, co-corresponding author of the investigation, Sterling Professor of Chemistry, and professor of molecular, cellular, and developmental biology.
This short animation revealing the polymer synthesis.
Ribosomes string together amino acids into long polymer chains that overlap into special structures — the proteins found in each living cell. The arrangement of amino acids required to make every protein is encoded hereditarily and decoded by the ribosome. Researchers like co-corresponding author Dieter Söll, Sterling Professor of Molecular Biophysics and Biochemistry and professor of chemistry, have invested decades making sense of how to bring novel amino acids into proteins.