Researchers Develop New Technology for Genome-Editing a Wide Range of Mutations in Living Organisms

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Now, Salk Institute researchers have formed a new tool — dubbed SATI — to edit the mouse genome, enabling the team to aim a wide range of mutations and types of cells.

The new genome-editing technology, described in Cell Research, could be expanded for use in a broad range of gene mutation conditions such as Huntington’s disease and the rare premature aging syndrome, progeria. “This study has shown that SATI is a powerful tool for genome editing,” says Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper. “It could prove instrumental in developing effective strategies for target-gene replacement of many different types of mutations, and opens the door for using genome-editing tools to possibly cure a broad range of genetic diseases.”

Source: A novel technology for genome-editing a broad range of mutations in live organisms: Scientists develop a new gene-editing tool that could help treat many disorders caused by gene mutations — ScienceDaily

First Gene Drive in Vertebrates using CRISPR-Cas9 Technology

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Gene drive

Gene drive, a genetic engineering innovation that pushes generation to acquire a specific allele from one parent more as often as possible than usual, has just worked in insects. Presently, specialists show it can prevail in vertebrates as well. In an investigation distributed in Journal Nature, the researchers depict a methodology that utilizes CRISPR-Cas9 to change the female mouse germline and drive the expression of white fur and a red fluorescent protein.

The group concentrated on the gene Tyrosinase, which decides coat color and would give the specialists a simple to-picture readout of whether their designed gene had been replicated. They embedded the gene drive containing a guide RNA to lead Cas9 to Tyrosinase and a gene for a red fluorescent protein into Tyrosinase’s fourth exon.

Reference:

Grunwald, H. A., et al. (2018). “Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline.” 362558.

CRISPR Researcher Who Gene Edited Human Babies is Being Held by Secretive Guards

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He Jiankui

Manifest

After Chinese researcher He Jiankui stunned established researchers by declaring a month ago that he had altered the genes of human children, he bafflingly vanished.

Also, presently he’s been found. The New York Times reports that guards are holding He in a guesthouse at his college, the Southern University of Science and Technology. It’s hazy whether the guard work for the Chinese government, the college, or another association — yet their essence is the most recent sign that He’s transgressive research upset the sensitive equalization of the hereditary genes look into network and administrative frameworks, provoking vengeance from amazing interests.

Informally dressed Guards

The Chinese government censured He’s work after he reported it, propelling a study and restricting him from proceeding with his research. What was misty, in any case, was whether He’s vanishing was a consequence of him hiding out or being held some place.

Presently the Times has discovered that He is remaining at a college guesthouse ordinarily used to house visiting researchers, where twelve casually dressed guards declined to recognize themselves to a Times correspondent. He can impart over email and telephone calls, as indicated by the Times, and has compared with business associates.

“He was greatly flippant to the representatives, accomplices and financial specialists,” said Liu Chaoyu, with whom He helped to establish the gene testing organization Vienomics, in a meeting with the Times. Liu last observed He the day preceding the conference at which he unveiled the presence of the gene altered children. “He didn’t examine anything with us before he made his declaration and we needed to manage every last bit of it out of the blue.”

Unexpected stunning display

The college and Shenzhen police both declined to remark to the Times. Actually, all representatives of the college have been banished from addressing the press, as indicated by a message gotten by the paper.

What’s unmistakable is that He’s exceptional work sent shockwaves through the research biological community as well as through the incredible apparatus of global government — and as the adventure of his treatment in the wake of the declaration unfurls, it could be a guide to the difficulties different specialists would confront on the off chance that they emulate his example.

Credits:

Futurism