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Layers of Protein Coating Augment Viral Infections to Alzheimer’s Disease

New research from Stockholm University and Karolinska Institute demonstrates that infections interface with proteins in the biological liquids of their host which results in a layer of proteins on the viral surface. This layer of proteins makes the infection progressively irresistible and encourages the arrangement of plaques normal for neurodegenerative illnesses, for example, Alzheimer’s disease.

Are infections in any condition? Well… both. Infections can just repeat inside living cells and adventure the cell apparatus of their host to their advantage. Be that as it may, before entering a host cell, infections are simply nanometer-sized particles, fundamentally the same as counterfeit nanoparticles utilized in therapeutic applications for analysis and treatment. Researchers from Stockholm University and Karolinska Institutet have discovered that infections and nanoparticles share another significant property; the two of them become secured by a layer of proteins when they experience the biological liquids of their host before they discover their objective cell. This layer of proteins superficially impacts their biological movement essentially.

“Envision a tennis ball falling into a bowl of milk and grains. The ball is promptly secured by the sticky particles in the blend and they stay on the ball when you remove it from the bowl. Something very similar happens when an infection gets in contact with blood or lung liquids that contain a large number of proteins. A significant number of these proteins quickly adhere to the viral surface shaping a supposed protein crown”, Kariem Ezzat of Stockholm University and Karolinska Institute clarifies.

Reference:

Kariem Ezzat, et al., “The viral protein corona directs viral pathogenesis and amyloid aggregation,” Nature Communications volume 10, Article number: 2331 (2019)

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