Gum Disease May Trigger Alzheimer


Hints of the bacterium Porphyromonas gingivalis, which causes chronic gum disease, have been found in the brains of individuals who had Alzheimer‘s disease. The outcome proposes the bacterium may assume a job in driving the improvement of the disease, research delivered in Science Advances.

Specialists saw brain tissue from post-mortems of people with and without Alzheimer’s disease and found a larger part of those with the infection had more elevated amounts of a compound called gingipains, which is sourced by P. gingivalis. They likewise examined the chemical’s belongings in the brains of mice, and found that it made the animals create indications of Alzheimer’s. The outcomes demonstrate gingipains is the “primary driver of Alzheimer’s disease,” consider coauthor Steve Dominy, a neurologist at Cortexyme, Inc., an organization creating medications for the diseases. The new research is one of a developing number that recommend microorganisms assume a job in Alzheimer’s disease.


Dominy, S. S., et al. (2019). “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.”  5(1): eaau3333.

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