First Gene Drive in Vertebrates using CRISPR-Cas9 Technology

Gene drive

Gene drive, a genetic engineering innovation that pushes generation to acquire a specific allele from one parent more as often as possible than usual, has just worked in insects. Presently, specialists show it can prevail in vertebrates as well. In an investigation distributed in Journal Nature, the researchers depict a methodology that utilizes CRISPR-Cas9 to change the female mouse germline and drive the expression of white fur and a red fluorescent protein.

The group concentrated on the gene Tyrosinase, which decides coat color and would give the specialists a simple to-picture readout of whether their designed gene had been replicated. They embedded the gene drive containing a guide RNA to lead Cas9 to Tyrosinase and a gene for a red fluorescent protein into Tyrosinase’s fourth exon.


Grunwald, H. A., et al. (2018). “Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline.” 362558.

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