Discovery of Exosomes Associated to Spread Cancer from Chemoresistant Tumors in Mice Model


In a few patients with cancer growth, tumors don’t contract because of chemotherapy and these patients are bound to create metastatic tumor. Mouse research have appeared for some cure safe cancers, chemotherapy can really advance metastasis. Presently, an investigation distributed on December 31 in Nature Cell Biology interfaces the spread of breast cancer from safe tumors in mice to extracellular vesicles these disease cells emit and demonstrates an uptick in their capability to cause metastasis after treatment with some chemotherapeutic drugs.

“We were astounded to see that chemotherapy was upgrading this procedure of metastasis, intervened by the vesicles,” says Michele De Palma, a cancer scientist at the École Polytechnique Fédérale de Lausanne and one of the paper’s authors. “This was very outlandish.”

Numerous kinds of cells create extracellular vesicles, known as exosomes when they’re a specific size, bundles of biomolecules that are sent to different goals in the body. For disease, specialists presume they are associated with seeding new cancers far from the first tumor. “They convey tumor material sheltered by a layer and they can travel long distances in the body and perhaps have an impact at a far off area,” says Mikael Pittet, a cancer immunologist at Massachusetts General Hospital and Harvard Medical School, who was not included with the work.


I. Keklikoglou et al., “Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models,” Nature Cell Biologydoi:10.1038/s41556-018-0256-3, 2018.

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